A sore throat, painful mouth ulcer, or aching gums can make even simple things like talking, eating, and swallowing feel exhausting. If you have ever stood in the pain relief aisle at Boots, Tesco, or your local pharmacy looking for fast, targeted relief, you have probably come across Difflam Spray. It is one of the most widely recommended throat and mouth sprays in the UK, available both over the counter and on NHS prescription, and it works in a slightly different way to most other sore throat remedies.
This complete UK guide explains everything you need to know about Difflam Throat Spray in plain English. We will cover what it is, how it works, what it treats, how to use it correctly for adults and children, the recommended dose for tonsillitis and other conditions, side effects, ingredients, safety in pregnancy, BNF guidance, where to buy it (including Tesco and other supermarkets), how much it costs, and how long it lasts once opened.
What Is Difflam Spray?
Difflam Spray is a metered dose pump spray used to relieve pain and inflammation in the mouth and throat. The active ingredient is benzydamine hydrochloride 0.15% w/v, which belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Unlike ibuprofen or naproxen, however, benzydamine is applied locally rather than swallowed, so it works directly on the painful area instead of being absorbed throughout the body.
Each 30ml bottle delivers a fine, measured spray through a long nozzle that can reach the back of the throat. It is available without a prescription from UK pharmacies, supermarkets like Tesco and Asda, and online pharmacies, although staff may ask a few questions before selling it to make sure it is suitable for you.
What Does Difflam Spray Do?
Difflam Spray does three main things at the site of pain:
- Reduces inflammation by blocking the production of prostaglandins, the natural chemicals your body releases when tissue is injured or infected.
- Numbs the painful area with a mild local anaesthetic effect, giving fast, targeted relief that often kicks in within minutes.
- Soothes redness, swelling, and a feeling of heat in the throat, gums, tongue, or inner cheeks.
Because it acts directly on the sore tissue, very little of the medicine enters the bloodstream. That is one reason it can be used in young children and elderly patients who often need to avoid stronger systemic painkillers.
What Is Difflam Throat Spray Used For?
Difflam Throat Spray is licensed for short-term relief of painful inflammatory conditions of the mouth and throat. UK pharmacists commonly recommend it for:
- Sore throat from colds, flu, or viral infections
- Pharyngitis and laryngitis
- Mouth ulcers (aphthous ulcers)
- Sore, inflamed gums
- Pain after dental procedures, extractions, or oral surgery
- Discomfort caused by dentures or braces
- Pain following tonsillectomy or use of a naso-gastric tube
- Sore tongue and inflamed tissue inside the cheek
Difflam Spray for Tonsillitis
Tonsillitis is one of the most common reasons people search for Difflam. Because tonsillitis causes severe inflammation at the back of the throat, the long nozzle on Difflam Spray is genuinely useful, it can deliver the medicine right onto the swollen tonsils where lozenges and warm drinks struggle to reach. Used alongside paracetamol or ibuprofen, plenty of fluids, and rest, Difflam can make swallowing significantly more comfortable while your immune system or antibiotics deal with the underlying infection.
It is important to understand that Difflam treats the symptoms of tonsillitis, not the cause. If your tonsillitis is bacterial (most often caused by Streptococcus), you may still need antibiotics from your GP or the NHS Pharmacy First service. Speak to a healthcare professional if you have a high fever, white patches on your tonsils, swollen neck glands, or symptoms that last more than a few days.
Does Difflam Spray Kill Bacteria?
This is one of the most common questions about Difflam, and the honest answer is no, not really. Difflam Spray is not an antibiotic. Its job is to reduce pain and inflammation, not to kill bacteria or viruses.
That said, benzydamine has been shown in laboratory studies to have some mild antimicrobial and antibacterial properties at high concentrations, but this is a minor secondary effect. You should not rely on Difflam Spray to clear an infection. If your sore throat is caused by bacteria such as strep, you will still need an antibiotic prescribed by a GP or pharmacist. Difflam simply makes the symptoms much more bearable while the infection is treated.
Difflam Spray Ingredients
The active and inactive ingredients in Difflam Throat & Mouth Spray (30ml) are:
- Active ingredient: Benzydamine hydrochloride 0.15% w/v (each puff delivers 175 microlitres containing 262.5 micrograms of benzydamine hydrochloride)
- Ethanol (96%)
- Glycerol
- Saccharin (for taste)
- Mint flavouring
- Polysorbate 20
- Methyl parahydroxybenzoate (E218) as a preservative
- Sodium hydrogen carbonate
- Purified water
Each spray contains a very small amount of alcohol (around 0.351ml of beer equivalent or 0.140ml of wine equivalent per puff). This is generally not a concern, but it is worth being aware of if you avoid alcohol for medical or religious reasons. Difflam Spray is gluten-free, lactose-free, and sugar-free.
How to Use Difflam Spray
Using Difflam Spray correctly makes a noticeable difference to how well it works. Follow these steps:
- Hold the bottle upright. The spray is designed to work in this position only.
- Lift the spray arm to a 90-degree angle until it is horizontal to the bottle. Do not bend it any further or in another direction.
- Prime the spray on first use. Point the nozzle away from your face and anyone else, then press the green plunger down firmly several times until a fine mist appears.
- Aim the nozzle at the sore area in your mouth or at the back of your throat.
- Press the green plunger the correct number of times for your dose (one push equals one puff).
- Wipe the nozzle with a clean tissue after use to prevent it blocking.
- Push the spray arm back down into the closed position to stop accidental release.
Try not to eat or drink immediately after using the spray so the medicine has time to work. Avoid very hot food and drinks for a while afterwards too, because the numbing effect can make it harder to feel if something is burning your mouth.
Keep the spray well away from your eyes. If any accidentally gets in, rinse them straight away with plenty of clean water.
Difflam Spray Dosage (Including BNF Guidance)
The recommended Difflam Spray dosage, in line with the BNF (British National Formulary) and the manufacturer’s UK product information, is as follows:
Adults, Adolescents (over 12) and the Elderly
- 4 to 8 puffs sprayed onto the sore area every 1.5 to 3 hours as needed.
Children Aged 6 to 12 Years
- 4 puffs to the sore area every 1.5 to 3 hours as needed.
Children Under 6 Years
- 1 puff per 4 kg of body weight, up to a maximum of 4 puffs, every 1.5 to 3 hours.
- For example, a 12 kg child would have 3 puffs; a 16 kg or heavier child would have the maximum 4 puffs.
Difflam Spray should not normally be used for more than 7 days in a row unless your doctor or dentist tells you otherwise. If your symptoms have not improved within 3 days for mouth ulcers, or 7 days for a sore throat, please speak to a pharmacist or GP. The BNF lists Difflam under the broader entry for benzydamine hydrochloride, where the same dosing applies.
Difflam Spray for Kids
Parents often ask whether Difflam Spray is safe for children, and the good news is that it can be used in children from a very young age, but the dose is strictly weight-based for younger kids.
The licensed UK product information allows Difflam Throat Spray to be used in children, with most online pharmacies stating it is suitable from around 1 month of age upwards (always check the patient information leaflet supplied with your bottle, as some retailers and product packs differ). For children aged 6 to 12, give 4 puffs every 1.5 to 3 hours. For children under 6, work out the dose using their weight (1 puff per 4 kg, up to a maximum of 4 puffs).
A few practical tips when using Difflam Spray for kids:
- Aim the spray at the inside of the cheek or the visibly sore area rather than down the throat for very young children.
- Tell them they may feel a brief stinging or numb sensation, this is normal and passes quickly.
- Keep them sitting upright when you use it, never lying down.
- Do not use the spray for longer than 7 days without advice from a pharmacist or GP.
- If your child has asthma, has had reactions to aspirin or other NSAIDs, or has any other long-term condition, check with a pharmacist before use.
Difflam Spray and Pregnancy
If you are pregnant, planning a pregnancy, or breastfeeding, you should not use Difflam Spray unless your doctor or midwife specifically advises you to. The official UK patient information leaflet states clearly that Difflam Spray should not be used during pregnancy unless clearly necessary, and should not be used while breastfeeding unless considered essential by a doctor.
Even though only a small amount of benzydamine is absorbed when used as a spray, all NSAIDs are treated with caution during pregnancy, particularly in the third trimester. Always speak to your GP, midwife, or a pharmacist before using any sore throat product if you are pregnant. They can recommend a safer alternative such as paracetamol, simple salt-water gargles, or honey and lemon drinks.
Difflam Spray Side Effects
Most people use Difflam Spray without any problems. When side effects do happen, they are usually mild and short-lived. Possible side effects include:
Common (affecting up to 1 in 10 people)
- Numbness in the mouth or throat
- A brief stinging or tingling sensation where the spray is applied
Uncommon to Rare
- Dry mouth or an unusual taste
- Itching, rash, or nettle rash (urticaria)
- Skin sensitivity to sunlight
Very Rare but Serious
- Spasm of the vocal cords causing breathing difficulty (laryngospasm)
- Asthma-like symptoms or bronchospasm, especially in people with a history of asthma or aspirin sensitivity
- Severe allergic reaction (anaphylaxis), with swelling of the lips, face, tongue, or throat, difficulty breathing, chest tightness, or severe itching
Stop using Difflam Spray immediately and seek urgent medical help if you have any signs of a severe allergic reaction. If the stinging sensation continues or becomes uncomfortable, stop using the product and speak to a pharmacist. You can report any suspected side effect through the MHRA Yellow Card Scheme at yellowcard.mhra.gov.uk.
Who Should Not Use Difflam Spray?
Difflam Spray is not suitable for everyone. Speak to a pharmacist or GP before using it if you:
- Are allergic to benzydamine hydrochloride or any of the other ingredients
- Have ever had an allergic or asthma reaction to aspirin or other NSAIDs (such as ibuprofen, naproxen, or diclofenac)
- Have asthma, especially aspirin-sensitive asthma
- Are pregnant or breastfeeding
- Are using other medicines that may interact, particularly other anti-inflammatory products
Difflam Spray Tesco, Boots, Asda and Other UK Retailers
Difflam Throat & Mouth Spray is widely available across the UK. You can typically buy it from:
- Tesco (in larger Extra and superstore branches with a pharmacy counter, plus tesco.com)
- Boots (in store and online, age restriction of 16+ applies online)
- Asda in-store pharmacies
- Superdrug and Sainsbury’s pharmacies
- LloydsPharmacy and Well Pharmacy
- Independent community pharmacies across the UK
- Reputable UK online pharmacies registered with the General Pharmaceutical Council (GPhC)
If you are buying Difflam Spray from Tesco, you will usually find it in the medicine aisle near other sore throat remedies, or behind the pharmacy counter where staff can advise on suitability. Some stores keep it as a Pharmacy (P) medicine, which means you may be asked a few quick questions before purchase.
Difflam Spray Price in the UK
The Difflam Spray price varies depending on where you buy it. As a rough UK guide for a single 30ml bottle:
- Supermarket pharmacies (Tesco, Asda, Sainsbury’s): around £6.50 to £8.50
- Boots and Superdrug: typically £7.99 to £9.50
- Online UK pharmacies: from around £6.00 to £8.00, sometimes with delivery charges
- NHS prescription charge (England): the standard prescription fee per item if dispensed on the NHS, which may be cheaper or more expensive than buying over the counter depending on your situation
Prices change regularly, so it is always worth comparing two or three retailers, especially online. If you are buying multiple items or have a recurring need, an NHS prescription prepayment certificate (PPC) can sometimes work out cheaper.
How Long Does Difflam Spray Last Once Opened?
Once you have opened Difflam Spray, it can typically be used until the expiry date printed on the bottle and outer carton, provided it has been stored correctly. There is no separate “use within X days of opening” instruction on most UK Difflam Spray packs because the bottle is sealed and metered.
To get the longest shelf life and best performance from your bottle:
- Store it upright, below 30°C, away from direct sunlight and heat.
- Do not put it in the fridge or freezer.
- Keep the spray arm folded down between uses to prevent leakage and contamination.
- Wipe the nozzle clean after each use.
- Never share your spray with someone else, this is for hygiene reasons even within the same family.
- Always check the printed expiry date and dispose of any unused medicine safely (your local pharmacy can take it back).
If the spray suddenly tastes different, looks discoloured, or stops working properly, return it to your pharmacist rather than using it.
Difflam Spray vs Other Sore Throat Treatments
UK shoppers often compare Difflam Spray to other sore throat options. Here is how it stacks up:
- Difflam vs Strepsils, Lockets, or Tyrozets: These are lozenges that mostly soothe and lubricate the throat, sometimes with a mild antiseptic. Difflam is genuinely anti-inflammatory and gives a stronger numbing effect.
- Difflam vs paracetamol or ibuprofen: Tablets work throughout the body to reduce pain and fever. Difflam works locally on the sore area only. Many people use both together, paracetamol or ibuprofen for the overall illness, and Difflam Spray for direct, fast-acting relief.
- Difflam Spray vs Difflam Oral Rinse: The spray is best for targeting one specific area, like a single ulcer or one inflamed tonsil. The rinse is better when soreness is spread across the whole mouth, although it is only suitable for adults and children over 12.
- Difflam vs antibiotics: Difflam treats symptoms only. If you have a bacterial throat infection that needs treating, your GP or NHS Pharmacy First pharmacist may prescribe antibiotics alongside it.
Frequently Asked Questions
Can I drink alcohol while using Difflam Spray?
The spray itself contains a tiny amount of alcohol, but using Difflam does not stop you having a normal drink. However, alcohol can irritate a sore throat further, so it is sensible to avoid it while you are unwell.
Can I use Difflam Spray with other medicines?
Difflam Spray is generally safe alongside paracetamol and ibuprofen. If you take prescription medication regularly, especially other NSAIDs, blood thinners, or asthma inhalers, check with your pharmacist first.
How quickly does Difflam Spray work?
Most people feel some relief within a few minutes of using it because of the local numbing effect. Full anti-inflammatory benefit builds up over the first day or two of regular use.
Is Difflam Spray available on the NHS?
Yes, it can be prescribed on the NHS by a GP, dentist, or pharmacist, and is listed in the BNF under benzydamine hydrochloride. It is also widely available to buy without a prescription as a Pharmacy (P) medicine.
Can I use Difflam Spray for a baby?
Difflam Spray is licensed for use in young children based on weight, but it should never be used in babies without specific advice from a GP, health visitor, or pharmacist. Always read the patient information leaflet that comes with your bottle.
What should I do if Difflam Spray is not working?
If your symptoms have not improved within 3 days for mouth ulcers or 7 days for a sore throat, stop using the spray and speak to a pharmacist or GP. You may need a different treatment, including possibly antibiotics if you have a bacterial infection.
The Bottom Line
Difflam Throat & Mouth Spray is one of the most effective over-the-counter options in the UK for fast, targeted relief from sore throats, mouth ulcers, gum pain, tonsillitis discomfort, and post-dental soreness. It works by reducing inflammation and numbing the painful area at the source, rather than going through your whole body like tablets.
Used at the correct dose, for no longer than 7 days at a time, and with sensible care around pregnancy, asthma, and very young children, it is a safe and well-tolerated medicine that has been trusted in the UK for decades. You can pick it up easily from Tesco, Boots, Asda, Superdrug, LloydsPharmacy, and registered online pharmacies, with prices generally between £6 and £10 for a 30ml bottle.
If you are unsure whether Difflam Spray is right for you or your child, speak to your local pharmacist. A two-minute conversation at the counter can save you days of unnecessary discomfort, and in many cases your pharmacist can also assess and treat sore throats directly through the NHS Pharmacy First service.
This article is for general information only and is not a substitute for professional medical advice. Always read the patient information leaflet supplied with your medicine, and speak to a GP, dentist, or pharmacist if you have any questions about your symptoms or treatment.